(i) minimal engineering approaches that guide lung epithelial organoid self-organization and assembly
(ii) microengineered hydrogels to recreate aspects of the complex pulmonary niche
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Zepp, J.A., Morley, M.P., Loebel, C., Kremp, M.M., Chaudhry, F.N., Basil, M.C., Leach, J.P., Liberti, D.C., Niethamer, T.K., Ying, Y., Jayachandran, S., Babu, AS. Zhou, S., Frank, D.B., Burdick, J.A., Morrisey, E.E., Genomic, Epigenomic, and Biophysical Cues Controlling the Emergence of the Lung Alveolus, Science, in press.
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Illustration: iPSC-derived alveolar type 2 cell organoids in hyaluronic acid-based hydrogels (scale bar 100 µm).