research themes:
(i) minimal engineering approaches that guide lung epithelial organoid self-organization and assembly
(ii) microengineered hydrogels to recreate aspects of the complex pulmonary niche
Relevant papers:
Zepp, J.A., Morley, M.P., Loebel, C., Kremp, M.M., Chaudhry, F.N., Basil, M.C., Leach, J.P., Liberti, D.C., Niethamer, T.K., Ying, Y., Jayachandran, S., Babu, AS. Zhou, S., Frank, D.B., Burdick, J.A., Morrisey, E.E., Genomic, Epigenomic, and Biophysical Cues Controlling the Emergence of the Lung Alveolus, Science, in press.
Zepp JA, Zacharias, WJ, Frank DB, Cavanaugh CA, Zhou S, Morley MP and Morrisey EE. (2017) Distinct mesenchymal lineages and niches promote epithelial self-renewal and myofibrogenesis in the lung. Cell 170(6): 1134-1148.e10.
Jacob A, Morley M, Hawkins F, [...] Beers MF, Kotton DN (2017) Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells. Cell Stem Cell 5;21(4):472-888.e10.
Dye BR, Youngblood RL, Oakes RS, Kasputis T, Clough DW, Spence JR, Shea LD. (2020) Human lung organoids develop into adult airway-like structures directed by physico-chemical biomaterial properties. Biomaterials 119757.
Illustration: iPSC-derived alveolar type 2 cell organoids in hyaluronic acid-based hydrogels (scale bar 100 µm). 
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